Dr. Philip Griebel, D.V.M., Ph.D.
Contact
Responsibilities:
♦ Program Manager – Pathogenomics
♦ Project Leader – BSE Vaccine Development; Johne's Disease
♦ Member of Science Management Team
♦ Member – Immune Modulation Using CpG Motifs; Neonatal Vaccines; VIDO Beef Technical Group
Education:
♦ Department of Veterinary Microbiology, University of Saskatchewan, Ph.D., 1988, "BHV-1 Infection and Leukocyte Function”
♦ Western College of Veterinary Medicine, University of Saskatchewan, Veterinary Medicine and Surgery, 1981 |
Major accomplishments:
♦ Identified novel method of fetal immunization through oral delivery of DNA vaccines. Subsequent investigations confirmed that this can induce protective immunity in the newborn. These observations have led to the filing of a patent.
♦ Member of the VIDO team that developed a novel model for the analyses of mucosal immune responses in the small intestine of ruminants. This model has subsequently been used to evaluate the function of gut-associated lymphoid tissue in the newborn and to analyze mucosal immune responses induced by potential vaccine antigens and oral vaccine delivery systems. This model system is now being used at VIDO to investigate host responses (sheep, cattle, and chicken) to viral and bacterial intestinal pathogens.
♦ Developed a novel culture system for ruminant B cells, crucial to healthy immune responses, that supports study of the control, activation and differentiation of mucosal B cells.
♦ Actively involved in the characterization of the biological effects of CpG ODN molecules, a novel class of molecules that activate the innate, or natural, immune system. Performed investigations that provided significant insight into CpG ODN
selection, formulation, and delivery.
♦ Maintain a strong interest in the transfer of knowledge gained from immunological research to relevant clinical applications. |
