VIDO-InterVac

Vaccine and Infectious Disease Organization -
International Vaccine Centre

Chlamydia trachomatis – animal model and vaccine development

Project Leaders: Jo-Anne Dillon, Volker Gerdts, Heather L. Wilson

Chlamydia trachomatis is one of the most common sexually transmitted bacterial pathogens. The bacteria primarily causes urogenital mucosal infections and left untreated may produce severe complications including pelvic inflammatory disease, infertility and ectopic pregnancies in women, prostatitis, epididymitis and involuntary infertility in men.

A porcine model for chlamydia infections was developed to characterize the host response to infection and to develop novel vaccine candidates. Our research has indicated this model can be successfully used to study pathology, pathogenesis and immune responses to infections with Chlamydia spp. This adds to the evidence that porcine models are promising tool for the development of novel vaccines against human sexually transmitted infections, and that the model may act as either an intermediate between mouse and non-human primate models or as a substitute for the latter during the development of vaccines for use in human clinical trials.

Objectives:

  • Develop a porcine model for Chlamydia trachomatis
  • Development of a vaccine for C. trachomatis