Vaccine and Infectious Disease Organization -
International Vaccine Centre

Development of a vaccine for contagious bovine pleuropneumonia

Project Team: Andrew Potter, Volker Gerdts, Jose-Perez Casal, T. Prysliak, T. Maina

Contagious Bovine Pleuropneumonia (CBPP) is a devastating disease of African cattle caused by Mycoplasma mycoides subsp. mycoides (Mmm). In collaboration with the Kenya Agricultural and Livestock Research Organisation (KALRO), and the International Livestock Research Organization (ILRI), VIDO-InterVac is developing a heat-stable and cost effective subunit vaccine against the disease.

We have identified vaccine targets using reverse vaccinology. Several recombinant antigens used in experimental vaccines provided protection to cattle challenged with a virulent strain of Mmm. Trials are underway to select the best antigen-adjuvant combination as assess vaccine safety. .