Vaccine and Infectious Disease Organization -
International Vaccine Centre

Development of a vaccine for Mycoplasma bovis in cattle

Project Team: Jose Perez-Casal, T. Prysliak, T. Maina

Mycoplasma bovis can cause chronic bronchopneumonia and polyarthritis in cattle. The bacterium is controlled by quarantine and antibiotic use as available vaccines lack efficacy.

To better protect feedlot cattle, we are developing a protective vaccine based on improved M. bovis pathogenesis knowledge. Reverse vaccinology was used to identify M. bovis antigens. An approach successfully used to develop the first recombinant vaccine against CBPP.

Mycoplasma bovis is also emerging as an important pathogen in farmed bison. It causes severe respiratory disease and high mortality with losses of 20-25% in affected herds. With collaborators in Alberta and the United States Department of Agriculture we are studying the disease epidemiology to compare isolates from bison and cattle for phenotypic traits.