VIDO-InterVac

Vaccine and Infectious Disease Organization -
International Vaccine Centre

Development of vaccines to prevent colonization and infection of poultry by Salmonella enteritidis serovars Enteritidis and Typhimurium

Project Leaders: Wolfgang Köster (Koester), Brenda Allan, Andrew Potter

Zoonotic bacterial pathogens such as Salmonella enterica serovars Enteritidis (SE) and Typhimurium (ST) can pose a significant food safety risk. As harmless commensals in poultry they do not cause disease, but when transferred to humans, usually through improper food handling or cooking, they can lead to severe food poisoning.

Vaccination to prevent colonization of poultry is one strategy to reduce the risk of contaminated food. Studies have shown that young chicks are the most susceptible to infection and provide the weakest link in the immunological control of SE. We believe that in ovo vaccination, in combination with existing disease control procedures, could be used to provide individual and flock immunity that would result in significant reductions in the risk of infection and contamination. In ovo vaccination strategies are being assessed to determine effectiveness in producing a protective immune response.

Objectives:

  • Development of an adenovirus based vaccine for the prevention and colonization of poultry by Salmonella
  • Development of a subunit vaccine directed against Salmonella Enteritidis to prevent colonization and infection of poultry