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Pathogenomics

Pathogenomics

 

The neonatal mucosal immune system responds very well to vaccination, suggesting mucosal vaccination has an unrealized potential to prevent infection by a broad range of mucosal pathogens.  Our innate mucosal immunity research program is focused on analyzing innate immune responses during persistent infection and developing relevant animal models for studying persistent enteric infection.


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Research Partners

 

VIDO-InterVac acknowledges the organizations that have provided funding for this research:

(Contract Research Partner: Fort Dodge, Intervet-Schering Plough, Virexx)


Members of this Research Group

 

Program Manager: Philip Griebel

Research Associate: Robert Brownlie

Graduate students: Patrick Fries, Rahwa Osman, Jean Potter, Mehran Yarahmadi

Research Technicians: Natasa Arsic, Jamille Heer, Yuij Popowych


Awards, Publications, Links

 

In September 2009, Philip Griebel was awarded a Canada Research Chair (Tier 1) in Neonatal Mucosal Immunology to identify vaccine strategies that will prevent or clear neonatal viral or bacterial infections.  This prestigious appointment is valued at $1.4 million over seven years and is renewable.    

 

For more information, please visit the webpage for the Canada Research Chair Program.

 

Below are some sample publications for this research group.  More information can be obtained in Publications and Patents.

  1. Griebel, PJ. 2009. Mucosal Vaccination of the Newborn: An Unrealized Potential. Expert Reviews of Vaccines 9 (1)1-3. (Editorial Comment)
  2. Jalal, S., Arsenault, R., Potter, A., Babiuk, L., Griebel, P.J, Napper, S. 2009. Genome to Kinome: Species-Specific Peptide Arrays for Kinome Analysis. Science Signaling 2, 1-11.
  3. Merimi, M., Ozkan, Y., Cleuter, Y., Griebel, P., Burny, A., Martiat, P., Van den Broeke, A. 2009. Epigenetics and leukemia: unraveling oncogenic processes in the BLV ovine model. Frontiers in Bioscience S1, 154-63.
  4. Gaertner, F.H., Babiuk, L.A., Mutwiri, G., Armstrong, J.M., Griebel, P.J 2009. Amended recombinant cells (ARCTM) expressing bovine IFN-g: An economical and highly effective adjuvant system. Vaccine 27, 1377-1385.
  5. Whale, T.A and Griebel, P.J. 2009. A Sheep in Wolf's Clothes: Can Neutrophils Direct the Immune Response? Veterinary Journal 180, 169-177.
  6. Aich, P., Potter, A.A., and Griebel, P.J. 2009. Modern approaches to understanding stress and disease susceptibility: A review with special emphasis on respiratory disease. International Journal of General Medicine 2, 1-14.
  7. Aich, P., Babiuk, L.A. Potter, A.A., Griebel, P.J. 2009. Biomarkers for Prediction of Bovine Respiratory Disease Outcome. OMICS A Journal of Integrative Biology 13 (3), 1-1.
  8. Brownlie, R., Zhu, J., Allan, B., Mutwiri, G.K., Babiuk, L.A., Potter, A., and Griebel, P.J. 2009. Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides. Molecular Immunology 46, 3163-70.
  9. Arsenault, RJ, Jalal S, Babiuk LA, Potter AA, Griebel PJ, and Napper S. 2009. Kinome Analysis of Toll-like Receptor Signaling in Bovine Monocytes. Journal of Receptors and Signal Transduction 29(6), 299-311