Vaccine and Infectious Disease Organization -
International Vaccine Centre

Development of novel vaccine for newborns against Lawsonia intracellularis (Ileitis)

Project Team: Heather L. Wilson, M. Obradovic, S. Hon Ng 

Lawsonia intracellularis is the causative bacterial agent of Ileitis/porcine proliferative enteropathy. Infection causes considerable economic impact on world pork production.

Research will identify antigens that, when targeted by antibodies, will prevent the invasion of bacteria into the epithelial cells of the pig gut. Our approach is based on empirical data, is high-throughput and evolves to include assessed of antigen targets on induction of cell-mediated immunity.

A vaccine against Ileitis will prevent loss of piglet growth from gut wall lesions, decrease herd mortality, and reduce pathogen shedding.