Chlamydia trachomatis and Neisseria gonorrhoeae
Project Team: Jo-Anne Dillon, Volker Gerdts, Heather L. Wilson
Chlamydia trachomatis and Neisseria gonorrhoeae are two of the most common sexually transmitted bacterial pathogens. These bacteria cause urogenital mucosal infections and, if left untreated, can lead to severe complications. These include pelvic inflammatory disease, infertility and ectopic pregnancies in women, and prostatitis, epididymitis and involuntary infertility in men. Vaccines are not available.
We developed a porcine model for Chlamydia infections to characterize the host response to infection and to evaluate novel vaccine candidates. Research indicates that this model can be used to study pathology, pathogenesis and immune responses to infections with Chlamydia. Steps are underway to establish a porcine model for gonorrhea infections. These models will allow us to evaluate novel experimental vaccine candidates in a more relevant animal model.