Development of a vaccine to prevent colonization of cattle by shiga toxin producing E. coli (STEC)

Project Leader: Andrew Potter

VIDO-InterVac developed an E. coli 0157:H7 vaccine for cattle, which was found to reduce shedding of the organism under both experimental and field conditions. A vaccine based on this prototype is fully licensed in Canada.

Other serotypes of E.coli, including O26, O103, and O111 produce Shiga toxin, colonize cattle and are capable of producing disease in humans. The current vaccine does not provide protection against colonization of cattle by these serotypes of STEC E. coli. The goal of our research is to produce a broad spectrum vaccine capable of providing protection against colonization by many serotypes of STEC E. coli.